Step 1 – Starting a new assessment

It is possible to run an assessment from any folder in CARES NG®, apart from the folder CARES Data which is read-only.

1. Go into the folder where you want to store your assessment
2. Choose Create > Assessment
3. You can now assign a name to your assessment. For this tutorial, type Test Assessment in the input field
4. Click on Create

Step 2 – Select the assessment type

Choose the type of assessment you want to run:

• Dietary
• Residential
• Exposure only

For this tutorial, select Residential.

Step 3 – Select the timeframe

The residential model has three timeframes:

• Short term
• Intermediate term
• Long term / chronic

Other two time-frames, multi-day and within-day, are shown by the wizard but they are not active for the time being. They will become active in future versions of the software, when the probabilistic version of the residential model will be implemented.
The wizard presents the short term timeframe selected by default, but it is possible to select any of the three timeframe. For this tutorial, select short term.
Click Next or on Population in the sidebar.

Step 4 – Select the demographics

The wizard contains as default populations the list of the regulatory populations determined by the guidelines of the Environmental Protection Agency. You can choose a single population or any combination of these populations. For this tutorial, select the populations Adults and Children 1-2.
Click Next or on Chemical/Toxicology in the sidebar.

Step 5 – Select the chemical / toxicology data

Please refer to page How to create a new table for creating a new chemical table. For this tutorial, create a table called Test Chemical Table with the data below. Click on Validate Data to validate the table; it is possible to insert only validated tables in all the different assessments that can be run in CARES NG®.

Residential population	chemical name	CAS number	route	time frame	POD	uncertainty factor	absorption factor	Q*	decay factor
Adults	Chemical X	1111-11-11	Oral	short_term	0.5	100	1

Insert a chemical table in the residential assessment
Click on Select a file to insert the Test Chemical Table into the wizard. A pop-up window allows you to browse the folders in the software and select the appropriate chemical table. Go to the folder where the Test Chemical Table was saved. Select the table Test Chemical Table and then click on Select.

Two new tabs, called Chemicals and Toxicology, appear in the assessment wizard. The tab Chemicals contains the list of the unique chemical names included in the chemical table just selected. In this example, there is only one chemical called Chemical X. Click on the check-box beside Chemical X to select it.

Click on Toxicology to see the toxicology data that are automatically selected by the program and that are deemed relevant for the assessment.

When you are happy with the selection of the chemical and toxicology data, click Next or on Products & Scenarios in the sidebar.

Step 6 – Select the product table

The Products & Scenarios step of the residential assessment requires the input of a Product table.

Create a new Product table
For this tutorial, create this Product table as below and call it Test Product Table.

Product ID	Product Name	Chemical ID	Scenario	Formulation	Application Method	Purity Perc Ai	Decay Factor	Max Appl Rate	Units	Consumer Product
P101	Prod1	1111-11-11	Gardens/trees	Granules	Hand dispersal	0.1	0.1	0.2	lb a.i./ft2	✓
P102	Prod2	1111-11-11	Lawns – turfs	Granules	Shaker can	0.5	0.25	0.7	lb a.i./can	✓
P103	Prod3	1111-11-11	Treated pets	Liquid concentrates	Sponge	0.3	0.4	0.4	g product/pet	✓

Insert a Product table in the residential assessment
In the Products & Scenarios step of the residential assessment, click on Select a file. The usual pop-up window opens and you can now select a Product table. Go to the appropriate folder, select Test Product Table and then click on

The wizard displays the list of the products contained into the Product table that can be analysed in the assessment. Select the products of interest. When a product is selected, the list of the scenarios where the product can be used into will appear beside the product code. Click on + to check and select the scenarios to be included into the assessment.

Click on Next or on Handler & Post-Application in the sidebar.

Step 7 – Select the handler and post-application parameters

In this step, it is possible to change the parameters of each combination of products and scenarios selected in the previous step. The parameters can be divided into two groups, handler and post-application parameters and the wizard presents you with two tabs, accordingly. In the handler tab you can find the list of all the parameters used to calculate the handler exposure for each combination product and scenario. Click on the product name, scenario and then dermal or inhalation; the parameter list will appear in the right panel. The Post Application tab shows the parameters used to calculate the post-application exposure. In order to see the values of the parameters, click on the product name, scenario, population, activity and then the sub-activity, if applicable, of interest; the parameter list will appear in the right panel.

Click on Next or on Statistics in the sidebar.

Step 8 – Select the calculations and statistics

This list of checkboxes allows you to calculate three risk indexes over the assessment outputs:

• Margin of Exposure (MOE)
• Hazard Index (HI)
• Aggregate Population Adjusted Dose (aPAD)

Please refer to the Aggregate risk characterization and Cumulative risk characterization pages for more information.
For this tutorial, select all the checkboxes.

Step 9 – Run the assessment

If you are happy with the selections made in the previous steps, click on the button Run at the bottom of the assessment wizard.

Now you are back in the folder where you have created the assessment. The new assessment is in the list of the assessments present in the folder. The assessment has a tag beside its name that shows the different stages of the assessment run.
The job running area appears in the top right of the screen. When the job running area disappears, the assessment run is finished.

If you click on the notification area a drop-down will be opened with the list of all the activities performed so far in the software (running assessments, importing tables, etc.). The activity related to the run of the assessment Test Assessment is the first in the list. The assessment can be in one of the two following states:

• Assessment Completed: no errors occurred during the run and now you can open the assessment and see the results. To do that, click on Open-assessment
• Assessment Failed: an error occurred during the run and the program was not able to calculate the results. It is possible to see a summary of the error by clicking on View-report

Step 10 – Inspect the output

After the assessment is successfully completed, you can inspect the output. The structure of the output is described in the page Output.

Click on Inputs to view a summary of the data and option selected and used in the assessment. From this window, it is possible to download all the output tables. Go to the section Export tables and click on the name of the table you want to download. A pop-up window opens giving you the possibility to change the settings of the csv file and to download the tables. When you are happy with the settings, click